The "Phase Down" of Dental Amalgam Restorations - What are the Criteria for Replacement and Indication?

ABSTRACT Objective: To guide professionals about the criteria for replacing amalgam restorations and inform them about the new guidelines regarding the use/indication of this (amalgam) material after the Minamata Convention - COP-4. Material and Methods: The articles were selected from the databases (PubMed, Scielo, Bireme), and relevant articles on the subject between the years 2003-2021 were selected. Recently, social media have been flooded with dental treatments that aim to perform restorations only with composite resins or other types of esthetic material and completely replace all dental amalgam restorations, irrespective of their time in place, size, and functionality. Results: Although improperly, it has been noted that this information reaches patients, and they are led to believe in the inaccurate data that is passed on, such as, for example, (that amalgam leads to) permanent contamination by mercury, causing systemic problems and the loss of the tooth. Conclusion: The "phase down" of amalgam in research and teaching has previously been observed in several countries worldwide; however, its use is still necessary given particular circumstances, which, theoretically, make it a material with exact indication.

Impact of dental restorations and removable prostheses on potentially malignant oral mucosal disorders in the general population.

STATEMENT OF PROBLEM: Dental restorations and removable dental prostheses have been considered as risk factors for potentially malignant disorders of the oral mucosa. It remains unclear whether amalgam, composite resins, and prosthesis materials can induce potentially malignant disorders. PURPOSE: The purpose of this clinical study was to determine the relationship between the presence of amalgam and composite resin restorations, crowns and fixed partial dentures, and removable prostheses in potentially malignant disorders. MATERIAL AND METHODS: The data of 6041 participants in the population-based Studies of Health in Pomerania (SHIP) were accessed. Potentially malignant disorders had been clinically diagnosed by calibrated dentists and documented with photographs. Dental treatment was subdivided into restored and replaced teeth. Dental restorations were subclassified as buccal composite resin or amalgam restorations. Prosthetic treatment was subclassified into removable partial or complete prostheses and definitive restorations with crowns and fixed partial dentures. RESULTS: In the maxilla, participants with removable prostheses had a higher incidence of potentially malignant disorders than participants not undergoing treatment with removable prostheses (OR 2.12; 95% CI: 1.08-4.18), but not in the mandible (OR 1.30; 95% CI: 0.67-2.53). The surfaces with composite resin restorations were associated with a slightly higher risk of mucosal lesions than those without the restorations (OR 1.04; 95% CI: 1.01-1.07). No significant association was found between amalgam restorations and mucosal lesions. CONCLUSIONS: Participants with removable prostheses have a higher risk of potentially malignant disorders. Composite resin restorations are associated with a higher risk of mucosal lesions, whereas no significant association was found between amalgam restorations and mucosal lesions.

Evidence-practice gap in treatment decisions about defective composite and amalgam restorations among Brazilian dentists

Better understanding of dentists' decision-making about defective restorations is needed to close the evidence-practice gap (EPG). This study aimed to quantify the EPG about defective restorations and identify dentist factors associated with this EPG. Methods: 216 dentists from São Paulo State, Brazil, completed a questionnaire about three clinical case scenarios involving defective composite restorations with cementum-dentin margins (case 1) and enamel margins (case 2), and an amalgam (case 3) restoration. Dentists were asked what treatment, if any, they would recommend, including preventive treatment, polishing, re-surfacing, or repairing the restoration, or replacing the entire restoration. Replacing the entire restoration in any of these three scenarios was classified as inconsistent with the evidence, comprising an EPG. Bivariate analyses using Chi-square, ANOVA, or multiple comparison tests were performed (p<.05). Results: for defective composite restorations, 49% and 55% of dentists chose to replace the entire restoration for cases 1 and 2, respectively. Twenty-nine percent of dentists chose to replace the entire amalgam restoration. Dentists were significantly more likely to choose to replace the defective amalgam restoration than the composite restoration with a defect at the cementum-dentin margins or the enamel margins (both at p < .001). Female dentists were more likely to choose a conservative treatment than male dentists for cases 1 (p=.034) and 2 (p=.009). Dentists with a higher percentage of patients interested in individualized caries prevention were also more conservative in case 1 (p=.045). Conclusion: a substantial EPG regarding treatment decisions for defective restorations exists, especially for composite restorations. This study adds to the international evidence that an EPG exists in this clinical area and that global strategies need to be developed to close the gap

Materiais restauradores em odontopediatria: preferência de pais e crianças e análise bibliométrica-altimétrica / Restorative materials in pediatric dentistry: children's and adults' preference and bibliometric-altmetric analysis

Atualmente, diversos materiais restauradores encontram-se disponíveis para aplicabilidade em Odontopediatria. Os avanços dos materiais restauradores conduzem à necessidade de novos estudos nessa temática. O presente estudo apresenta duas propostas de investigação: 1) Estudo transversal com objetivo de avaliar a preferência de pais/responsáveis e crianças quanto ao emprego do compômero colorido (Twinky Star®, Voco, Alemanha); 2) Estudo bibliométrico altimétrico com objetivo de analisar 50 artigos mais citados referente aos materiais restauradores utilizados em Odontopediatria e o alcance dessa informação científica nas mídias on-line. O estudo transversal envolveu 260 pares de pais/responsáveis e crianças de 5 a 11 anos de idade de dois serviços de saúde da região metropolitana de Belo Horizonte-MG. Exame quanto à cárie dentária foi realizado por examinadora calibrada para o critério da Organização Mundial da Saúde. Um manequim odontológico contendo restaurações com compômeros coloridos e materiais convencionais (resina composta, ionômero de vidro e amálgama) foi apresentado aos participantes do estudo e realizou-se inquérito sobre a preferência dos materiais dentários. O Questionário de Estilo e Dimensões dos Pais (PSDQ) e o Eysenck Personality Questionnaire Junior (EPQ-J) foram aplicados, este último apenas para pais/responsáveis de crianças de 5 e 6 anos de idade. Análises descritivas, bivariadas e regressão multivariada de Poisson foram realizadas. A maioria dos pais/responsáveis (74,2%) preferiu materiais convencionais. A idade da criança (p=0,006), a renda familiar (p= 0,001) e o nível de escolaridade (p< 0,001) associaram se a essa escolha. A análise multivariada demonstrou que crianças menores de 7 anos apresentaram 1,20 vezes maior probabilidade de escolher compômeros coloridos do que seus pares mais velhos (p< 0,001), assim como pais/responsáveis com menos de 11 anos de escolaridade e cujos filhos eram menores de 7 anos apresentaram 2,17 e 1,74 maior probabilidade para escolher compômeros coloridos, respectivamente. Concluiu-se que responsáveis com maior escolaridade apresentaram maior resistência às restaurações coloridas e crianças menores de 7 anos aceitaram melhor este material. O estudo bibliométrico-altimétrico adotou estratégia de busca em três bases (Web of Science, Scopus e Google Scholar), independente da data de publicação. Após seleção dos artigos por um grupo de cinco pesquisadores, em março de 2023, foram incluídos estudos que avaliassem qualquer material restaurador empregado em dentes decíduos e analisados dados referentes ao título, número de citações, país/continente, autoria, periódico, instituição, desenho do estudo, tipo de material restaurador, e escore altimétrico. Os artigos, publicados entre 1991 a 2002, apresentaram variação de citações de 19 a 113. Os autores com maior número de citações foram Qvist V e Teglers PT. O estudo experimental foi o principal delineamento de estudo observado e o cimento de ionomero de vidro foi o material mais reportado. A Europa foi o continente, e o Brasil, o país com maior número de citações. O escore altimétrico esteve presente em 23 artigos, com ênfase para dois artigos (43/6º e 73/7º). Concluiu-se que o cimento de ionômero de vidro foi o material mais estudado. Ficou evidente o distanciamento entre a posição dos trabalhos nas análises bibliométrica e altimétrica, apontando necessidade de disseminação da informação além dos círculos acadêmicos.

Currently, an arsenal of restorative materials is available for applicability in pediatric dentistry. The advances in restorative materials conducted to need for further studies in this thematic. The present study presents two investigation proposals: 1) Cross-sectional study aiming to evaluate the preference of parents and children regarding the use of colored compomer (Twinky Star®, Voco, Germany); 2) Bibliometric-altmetric study aiming to analyze the 50-most cited papers regarding to restorative materials used in pediatric dentistry and the dissemination of scientific information in online media. The cross-sectional study included 260 pairs of caregivers/children aged 5 to 11, in two public health services, in the metropolitan region of Belo Horizonte-MG. Examination for dental caries was performed by an examiner calibrated to the criteria of the World Health Organization. A dental mannequin containing colored compomers restorations and conventional materials (composite resin, glass ionomer cement and dental amalgam) was presented to the population and a survey was conducted about the preference of dental materials. Parents' Style and Dimensions Questionnaire (PSDQ) and Eysenck Personality Questionnaire Junior (EPQ-J) were applied, the last one only for parents/caregivers of children aged 5 to 6. Descriptive, bivariate and Poisson regression analyzes were performed. Most adults (74.2%) preferred conventional materials. Family income (p= 0.001) and education level (p< 0.001) were associated with its choice. Age up to 7 (p< 0.001) associated with children's choice for colored restorations (72.3%). Children younger than 7 had 1.20 higher probability to choose colored compomers than their older pairs, while adults with children younger than 7 and less than 11 years of schooling had 1.74 and 2.17 higher probability to choose colored compomers, respectively. It was concluded that caregivers with higher educational level showed greater resistance to use of colored restorations and children younger than 7 had better acceptance of colored material. The bibliometrics-altmetrics study adopted a search strategy in three databases (Web of Science, Scopus and Google Scholar), independent of the year of publication. After selection of papers by a panel of five researchers, in March 2023, any restorative material used in deciduous teeth was included and data about the title, number of citations, country/continent, authorship, journal, design of the study, type of restorative material, university and altmetrics score were analyzed. The papers, published between 1991 and 2002, ranged from 19 to 113 citations. The authors with the highest number of citations were Qvist V and Teglers PT. The experimental study was the main study design observed. Analyzing the continent and country with the highest number of citations, Europe highlighted and Brazil was predominant. The altmetric score was present in 23 papers, emphasizing two articles (43/6th and 73/7th). It was concluded that glass ionomer cement was the most studied material. A gap between the position of the papers correlating the bibliometrics and altmetrics analyzes was evident, demonstrating the need to disseminate the information beyond academic circles.

Assessment of Bite Forces in Restored Teeth with Different Commonly Used Restorative Materials: A Comparative Study

ABSTRACT Objective: To evaluate and compare bite force (BF) in permanent first molars restored with glass ionomer cement (GIC), composite and amalgam, and normal contralateral permanent first molars. Material and Methods: BF was recorded in decayed permanent first molars, which were filled with GIC (n=30), composite (n=30), and amalgam (n=30), and in healthy contralateral first molars (n=90) with Force Transducer Occlusal Force Meter and compared. Results: BF was significantly higher in normal teeth on the contralateral side compared to teeth restored with GIC and composite. However, in patients with amalgam restoration, though it was less compared to that on the contralateral side, it was not statistically significant (p>0.05). Conclusion: Restoring teeth with various filling materials may improve bite force. In the present study, it was found that the teeth restored with amalgam had higher bite forces in comparison to the other restorative materials used. However, it was not comparable to that observed in the normal tooth (control) on the contralateral side.

Ubiquitous toxicity of Mercuric Chloride in target tissues and organs: Impact of Ubidecarenone and liposomal-Ubidecarenone STAT 5A/ PTEN /PI3K/AKT signaling pathways.

BACKGROUND: Mercuric chloride (HgCl3) is categorized as class II B hazardous metal that is present in many occupational and environmental conditions. In the meantime, Hg exists in the environment in such an abundant manner, it is virtually impossible for humans to avoid exposure to different forms of Hg. In addition to environmental exposure, individuals may be exposed to Hg from dental amalgams, medicinal treatments and dietary sources. Nevertheless, Liposomal drug delivery system is a promising era in the field of Nano-medicine and have the advantageous of increasing drug bioavailability and retention phenomena in addition to targeting organ for all mentioned the present study was designed to investigate the hypothesis that messenger RNA gene expression of Signal transducer and activator of transcription- 5 A (STAT-5A), Phosphatase and tensin homolog (PTEN), phosphoinositol kinase (PI3K) and alpha serine/threonine-protein kinase (AKT) can trigger HgCl3 induced nephrotoxicity post Ubidecarenone and liposomal Ubidecarenone therapy. METHODS: HgCl3 toxicity was induced in rats via a dose of 5 mg/kg BW for one week followed by Ubidecarenone and liposomal Ubidecarenone therapy in a dose of 10 & 3 mg/kg BW for one month, respectively. Then kidney function tests, Glutathione and gene expression for PI3K, AKT, PTEN and STAT-5A was investigated. RESULTS: HgCl3 intoxication significantly up regulated PI3K, AKT, PTEN and STAT-5A signaling pathways meanwhile, Ubidecarenone and liposomal- Ubidecarenone treatment significantly reduced PI3K, AKT, PTEN and STAT-5A gene expression post HgCl3 intoxication with the liposomal regimen revealing the most significant impact. Furthermore, renal toxicity was confirmed via monitoring urea and creatinine which were modulated post Ubidecarenone and liposomal-Ubidecarenone treatment. Wide evidence declared that mercuric S-conjugates of small endogenous thiols (such as Hcy, NAC and Cys) are probably the main transportable forms of Hg2+ to the kidneys thus reduced glutathione was investigated which reflected a significant down regulation post Hgcl3 toxicity. CONCLUSION: liposomal drug delivery system including liposomal-Ubidecarenone can be considered as a prospective candidate for treating HgCl3 renal toxicity via modulating STAT-5A, PTEN, PI3K and AKT signaling pathways and via increasing retention time, bioavailability, shielding from macrophage recognition and targeting organs.

Norma técnica de salud para el uso del odontograma: NTS N° 188-MINSA/DGIESP-2022 / Technical health norm for the use of the odontogram: NTS N° 188-MINSA/DGIESP-2022

La publicación describe los criterios para el registro de datos de las características, anomalías patológicas de las piezas dentarias, así como el registro de procedimientos estomatológicos realizados para el uso y manejo del odontograma en las diferentes UPS, pudiendo ser utilizados en aspectos clínicos, legales, forenses, estadísticos, de investigación o docencia. Asimismo las pautas para estandarizar el gráfico y la nomenclatura básica para el registro de hallazgos clínicos en el odontograma, permitiendo a la comunidad de cirujanos dentistas manejar la misma información

Uma revisão de escopo de revisões sistemáticas sobre exposição humana ao mercúrio / A scoping review of systematic reviews on human exposure to mercury

Resumo: Introdução: a promulgação da Convenção de Minamata no Brasil em 2018 incentivou o cumprimento dos seus objetivos em reduzir o uso e a poluição por mercúrio. Objetivo: caracterizar a produção científica sobre exposição humana ao mercúrio e identificar lacunas de conhecimento a fim de subsidiar a tomada de decisão em saúde. Métodos: revisão de escopo de revisões sistemáticas e metanálises, sem restrição de idioma ou data de publicação, utilizando as bases PubMed, BVS e Cochrane Library. Resultados: 71 estudos atenderam aos critérios de elegibilidade, com 40 revisões sistemáticas, 30 metanálises e 1 overview. Amálgama dentário e contaminação alimentar e ambiental por atividades que utilizam mercúrio foram as fontes de exposição mais mencionadas. Os temas mais estudados contaram com transtornos mentais e comportamentais, assim como uso de biomarcadores e testes neurocomportamentais relacionados à exposição ao mercúrio. Discussão: lacunas como a exposição ocupacional ao mercúrio, uso em práticas tradicionais e em cosméticos apontam para a necessidade de mais estudos. As revisões identificadas podem oferecer subsídios para sínteses de evidências e protocolos de atenção à saúde de populações expostas, assim como para a elaboração de políticas públicas que visem o controle do uso e da exposição ao mercúrio.

Abstract: Introduction: in 2018, the promulgation of the Minamata Convention in Brazil encouraged compliance with its goals of reducing mercury use and pollution. Objective: to characterize the scientific production and identify the knowledge gaps to subsidize decision-making in healthcare on human exposure to mercury. Methods: a scoping review was carried out of systematic reviews and metanalysis, without language and publication date restriction, retrieved from the PubMed, BVS, and Cochrane Library databases. Results: a total of 71 studies met the eligibility criteria, of which 40 were systematic reviews, 30 meta-analyses, and one overview. Dental amalgam as well as food and environmental contamination by mercury-based activities were the most cited sources of exposure. Most studies focused on mental and behavioral disorders, as well as the use of biomarkers and neurobehavioral tests related to mercury exposure. Discussion: knowledge gaps on occupational exposure to mercury, mercury use in both traditional practices and cosmetics point to the need for further studies. The reviews identified could provide data for evidence synthesis and healthcare protocols for affected populations, as well as for elaborating public policies aimed at controlling mercury use and exposure.

Glass ionomer heated or not to identify bone defect created in rat calvaria / Ionômero de vidro aquecido ou não para identificação de defeitos ósseos criados em calvárias de ratos

Introduction: Some experimental models have been used to evaluate the use of biomaterials in bone regeneration. Among them are the critical size defects (CSD) created in rat calvaria. An experimental model has been described in the literature, in which "L" markings are performed on the margins of the bone defects in order to assist in the precise identification of these defects during laboratory processing and analysis of the results. In the proposed model, the "L" markings are filled with amalgam. Objective: The purpose of the present study was to evaluate the amalgam replacement of an experimental bony defect model in rat calvaria by heated or unheated glass ionomer. Material and method: 24 rats were used. A 5 mm CSD was created at each animal calvaria. Two "L" shaped markings were made 2 mm from the margins of the bone defect, filled with amalgam (Group AM), heated glass ionomer cement (Group GIh) or not (Group GI). The animals were euthanized 15 days postoperatively. The areas of the surgical defect and the L-shaped marking were histomorphometrically analyzed and the data were analyzed statistically (p <0.05). Result: There were no significant clinical, histological or methodological differences among the experimental groups. Conclusion: It can be concluded that GI can replace AM in the proposed experimental model and GI heating did not promote additional benefits.

Introdução: Alguns modelos experimentais têm sido usados para avaliar o uso de biomateriais na regeneração óssea. Entre eles estão os defeitos de tamanho crítico (DTC) criados em calvárias de ratos. Um modelo experimental foi descrito na literatura onde marcações em L são realizadas nas margens do defeito ósseo para auxiliar na identificação precisa desses defeitos durante o processamento laboratorial e análise dos resultados. No modelo experimental proposto, as marcações em "L" são preenchidas com amálgama. Objetivo: Avaliar a substituição do amálgama por ionômero de vidro aquecido ou não em um modelo experimental para identificação de defeito ósseo criado em calvária de ratos. Material e método: Foram utilizados 24 ratos. Um DTC de 5 mm de diâmetro foi criado na calvária de cada animal. Duas marcações em "L" foram realizadas a 2 mm das margens do defeito ósseo, preenchidas com amálgama (Grupo AM), ionômero de vidro aquecido (Grupo CIVaq) ou não (Grupo CIV). Os animais foram eutanasiados aos 15 dias pós-operatórios. A área do defeito cirúrgico e das marcações em "L" foram histomorfometricamente avaliadas e os dados estatisticamente analisados (p<0,05). Resultado: Não houve diferença estatisticamente significativa entre os grupos experimentais para as análises metodológicas, clínicas ou histomorfométrica realizadas. Conclusão: Dentro dos limites deste estudo, pode-se concluir que CIV pode substituir o AM no modelo experimental proposto e o aquecimento do CIV não promoveu benefícios adicionais.

Recomendaciones sobre la reparación de restauraciones de amalgama / Recommendations about the repair of dental amalgam restorations

Introducción: La reparación de restauraciones de amalgama, los materiales, las caras de los dientes de preferencia para realizarlas y su controversia con la contraparte de realizar reemplazos, es algo que amerita atención por los investigadores para lograr definiciones y protocolos precisos. Objetivo: Sistematizar sobre las recomendaciones de la literatura con respecto a la reparación de restauraciones de amalgama. Métodos: Se realizó una revisión cualitativa. Se plantearon criterios de inclusión y exclusión para la selección de los artículos. La búsqueda se realizó en Scopus y Pubmed. De las investigaciones resultantes de la búsqueda fueron decantados los artículos que no coincidían con el problema de investigación en cuestión, luego los que no cumplían los criterios de inclusión y exclusión. Se realizó una evaluación de la calidad y validez de los artículos seleccionados para ser incluidos en esta investigación y, finalmente, se le dio lectura a los textos completos y resúmenes para extraer los datos necesarios para completar la base de datos de la investigación. Quedaron un total de 27 artículos que fueron tamizados en una base de datos Excel, la que luego se exportó al software SPSS para su procesamiento estadístico. Resultados: El 44,4 por ciento y 55,6 por ciento de los artículos recomiendan reparar las restauraciones con amalgama y resina compuesta, respectivamente. Casi la mitad de los artículos (48,1 por ciento) no precisaron una cara del diente susceptible o no para realizar reparaciones. El 44,4 por ciento concluyen con que es un tratamiento recomendable. Conclusiones: Es recomendable realizar reparaciones de restauraciones de amalgama con amalgama dental y con resina compuesta. No está claramente definido cuál cara del diente es susceptible o no a recibir reparaciones y es un tratamiento que puede formar parte del arsenal terapéutico de los odontólogos(AU)

Introduction: The repair of amalgam restorations, the materials used, the tooth sides preferred to perform them, and the controversy with the replacement option, are all topics deserving the attention of researchers with a view to achieving accurate definitions and protocols. Objective: Systematize the recommendations available in the literature about the repair of amalgam restorations. Methods: A qualitative review was carried out. Inclusion and exclusion criteria were established for the selection of papers. The search was conducted in Scopus and Pubmed. Papers not related to the research problem at hand were the first to be discarded. Then those not meeting the inclusion and exclusion criteria. An evaluation was performed of the quality and validity of the remaining papers, and finally their full texts and abstracts were read to retrieve the data required to complete the database of the study. The 27 papers thus obtained were sifted in an Excel database, which was then exported to the SPSS software for statistical processing. Results: 44.4 percent and 55.6 percent of the papers recommend to repair restorations with amalgam and composite resin, respectively. Almost half (48.1 percent) do not state any preference for a specific tooth side to perform the repair. 44.4 percent recommend the treatment. Conclusions: It is advisable to perform repairs of amalgam restorations with dental amalgam and with composite resin. It is not clearly defined which tooth side is preferred to undergo the repair. This treatment may be part of the therapeutic arsenal of dentists(AU)

The protective role of selenium against dental amalgam-induced intracellular oxidative toxicity through the TRPV1 channel in DBTRG glioblastoma cells.

OBJECTIVE: The exposure to mercury (Hg) from dental amalgams is a suspected causative factor in neurological diseases. This study investigated the toxic effects of two different amalgam compositions related to Hg and the protective effects of selenium against the toxic effects of Hg through the TRPV1 channel in the human DBTRG glioblastoma cell line. METHODOLOGY: Six groups of the cells were organized. Analyses of cell viability, apoptosis, caspase 3 and caspase 9 activities, mitochondrial membrane depolarization, reactive oxygen species (ROS) production, and Western Blotting for protein expression levels were performed. RESULTS: Cell viability values were lower in amalgam with high copper (HCu) and low copper (LCu) groups independently of time but were increased by selenium and capsazepine (p<0.001 and p<0.05). Conversely, apoptosis rates, caspase 3 and caspase 9 expression, ROS formation, mitochondrial membrane depolarization, and protein expression levels were higher in the HCu and LCu groups but were decreased by selenium (p<0.001 and p<0.05). CONCLUSIONS: Selenium combined with an amalgam of either HCu or LCu decreases the toxic effects created by Hg in human DBTRG glioblastoma cells.

Malignant transformation of a clinically and histologically healed lichenoid lesion after amalgam removal: A case report and literature review.

Lichenoid contact lesions (LCLs) frequently develop in close contact with amalgam restorations and may regress after amalgam removal, especially when patch testing is positive to amalgam components. However, established criteria to define true LCLs healing are missing and clinical disappearance of the lesion may not always correspond to a complete regression of histological lichenoid tissue reaction. Similarly to other lichenoid lesions of the oral cavity, LCLs are included among potentially malignant disorders although its malignant transformation remains controversial. As a result, with no clear indications for neoplastic risk assessment, the management of patients with LCLs may be challenging. The present report describes the unusual case of an oral squamous cell carcinoma (OSCC) arising in the same site where 6 years before an amalgam-associated LCL had clinically and histologically healed after restoration replacement. A review of the few literature reports of amalgam-associated LCLs developing to OSCC is also provided.

Amalgam allergy and Burning Mouth Syndrom: treatment and 25 years recall / Alergia ao amálgama e Síndrome da ardência bucal: tratamento e 25 anos de proservação

Background: Burning mouth syndrome (BMS) is a non-neuropathic chronic orofacial pain condition, characterized by the presence of burning/warm sensation without specific mucosal lesions. Objective: The aim of the present clinical case report is to describe the positive outcome of dental treatment of a patient with BMS and followed up for 25 years. Data Treatment: This report describes the case of a 50-year-old black woman sought treatment for burning, and persistent swelling of tong (24h/day) occurring over years. Clinical evaluation of the oral environment revealed the tongue with cracking, darkened points areas, surrounded by whitish areas. Twelve teeth presented extensive amalgam restorations. Patch testing revealed a very strong hypersensitivity to Amalgam. All amalgam restorations were substituted by composite resin restorations. Results and Conclusion: Burning sensation disappeared completely after these restorations had been changed. After 25-year follow-up period, it was observed that burning sensation has never been felt anymore. Clinical Significance: Burning mouth syndrome is a chronic orofacial pain, usually without specific mucosal lesions. The etiology is complex and multifactorial and the treatment should be made specifically for each pacient. (AU)

Introdução: A síndrome de ardência bucal (SAB) é uma condição de dor orofacial crônica não neuropática, caracterizada pela presença de sensação de queimação/calor sem lesões específicas da mucosa. Objetivo: Oobjetivo do presente relato de caso clínico é descrever a evolução positiva do tratamento odontológico de uma paciente com SAB e o retorno após 25 anos. Tratamento dos Dados: Este relato descreve o caso de uma mulher negra de 50 anos que buscou tratamento por queimadura e edema persistente da língua (24h/dia) ocorrendo ao longo dos anos. A avaliação clínica da cavidade bucal revelou a língua com áreas fissuradas e áreas com pontos escurecidos circundadas por áreas esbranquiçadas. Doze dentes apresentavam restaurações extensas de amálgama de prata. O teste de contato revelou hipersensibilidade muito forte ao amálgama de prata. Todas as restaurações de amálgama de prata foram substituidas por restaurações de resina composta. Resultados e Conclusão: A sensação de queimação desapareceu completamente após a substituição das restaurações. Após um periodo de 25 anos, observou-se que a sensação de queimação nunca foi mais relatada. Significado Clínico: a síndrome da ardência bucal é uma dor orofacial crônica, geralmente sem lesões específicas da mucosa. A etiologia é complexa e multifatorial e o tratamento deve ser feito especificamente para cada paciente.(AU)

Cuerpo extraño (fragmento de amalgama intraóseo) de la mandíbula: informe de caso / Foreign body (intraosseous bone fragment) of the mandible: report of a case

Un cuerpo extraño es un objeto o una estructura que se incluye accidental o intencionalmente en la intimidad de los tejidos orgánicos de un individuo. Puede desencadenar importantes procesos inflamatorios/ infecciosos, dependiendo de su naturaleza, requiriendo en la mayoría de los casos su extracción quirúrgica, con el fin de evitar daños al paciente. Este trabajo tiene como objetivo informar un caso de cuerpo extraño (fragmento de amalgama) incluido iatrogénicamente en la exodoncia de un molar inferior derecho en un paciente que, después de 8 años, optó por hacerse un implante en el área y descubrió la inclusión de este material, siendo necesaria su extracción quirúrgica para la posterior colocación del implante dental en la región. Los autores destacan la necesidad de realizar una minuciosa inspección y toilette de la caja alveolar en el acto de la exodoncia, para evitar incluir cuerpos extraños en el sitio quirúrgico y evitar así, una nueva intervención en el área (AU)

Foreign body is an object or structure included accidentally or intentionally in the intimacy of the organic tissues of individuals. They can trigger important inflammatory / infectious processes, depending on its nature, requiring its surgical removal in most cases, to prevent damage to the patient. This study aimed to report a case of a foreign body (fragment of amalgam) iatrogenically included in extraction of a right lower molar in a patient who, after 8 years, opted to have an implant in the area and discovered the inclusion of this material, requiring its surgical removal for subsequent placement of a dental implant in the region. The authors highlight the need to perform a thorough inspection and toilet of the alveolar box in the act of extraction, to avoid including foreign bodies in the surgical site, avoiding further intervention in the area (AU)

The protective role of selenium against dental amalgam-induced intracellular oxidative toxicity through the TRPV1 channel in DBTRG glioblastoma cells

Abstract Objective The exposure to mercury (Hg) from dental amalgams is a suspected causative factor in neurological diseases. This study investigated the toxic effects of two different amalgam compositions related to Hg and the protective effects of selenium against the toxic effects of Hg through the TRPV1 channel in the human DBTRG glioblastoma cell line. Methodology Six groups of the cells were organized. Analyses of cell viability, apoptosis, caspase 3 and caspase 9 activities, mitochondrial membrane depolarization, reactive oxygen species (ROS) production, and Western Blotting for protein expression levels were performed. Results Cell viability values were lower in amalgam with high copper (HCu) and low copper (LCu) groups independently of time but were increased by selenium and capsazepine (p<0.001 and p<0.05). Conversely, apoptosis rates, caspase 3 and caspase 9 expression, ROS formation, mitochondrial membrane depolarization, and protein expression levels were higher in the HCu and LCu groups but were decreased by selenium (p<0.001 and p<0.05). Conclusions Selenium combined with an amalgam of either HCu or LCu decreases the toxic effects created by Hg in human DBTRG glioblastoma cells.

Evaluation of Effectiveness of Self-Adhesive Composites for Amalgam Repair with or Without Alloy Primer, in Terms of Shear Bond Strength / Evaluación de la efectividad de los compuestos autoadhesivos para la reparación de amalgamas con o sin imprimación de aleación, en términos de resistencia al cizallamiento

Abstract Purpose: The purpose of the present research was to evaluate the effectiveness of self-adhesive composites in amalgam repair as time-saving alternatives to universal bonding-universal composite materials, with or without the usage of Alloy Primer in terms of shear bond strength. Materials and Methods: Forty- two disc-shaped amalgam samples were prepared by condensing into 6×2 mm holes in acrylic resin blocks, sandblasted with 50 μm Al2O3 and randomly divided into 6 groups according to repair material [Constic (Group C), Fusio Liquid Dentin (Group FLD), Universal bonding+Universal composite (Group Control), Alloy Primer+Constic (Group APC), Alloy Primer+Fusio Liquid Dentin (Group APFLD), Alloy Primer+Universal bonding+Universal composite (Group APControl)]. After shear bond strength test, the fracture modes were determined under a digital microscope. Statistical analysis was performed using one-way analysis of variance and Tukey's post hoc test. Results: The highest shear bond strength values were obtained for Fusio Liquid Dentin, among the three repair materials when Alloy Primer was not applied (p<0.05). Usage of Alloy Primer increased shear bond strength values of the investigated repair materials to amalgam, except Fusio Liquid Dentin. Conclusion: Within the limitations of the present research, it can be concluded that; the investigated self-adhesive composite materials could be time-saving alternatives to the Universal bonding+Universal composite for the purpose of amalgam repair, in terms of shear bond strength. The clinicians could prefer Fusio Liquid Dentin self-adhesive composite material without Alloy Primer application for the purpose of amalgam repair in non-cooperative patients.

Resumen Propósito: El propósito de la presente investigación fue evaluar la efectividad de las resinas compuestas autoadhesivas en la reparación de amalgamas como alternativas que ahorran tiempo con respecto a las resinas compuestas universales de adhesión universal, con o sin el uso de Alloy Primer en términos de resistencia al cizallamiento. Materiales y métodos: Se prepararon 42 muestras de amalgama en forma de disco condensándolas en orificios de 6×2 mm en bloques de resina acrílica, arenadas con 50 μm de Al2O3 y divididas al azar en 6 grupos según el material de reparación [Constic (Grupo C), Fusio Liquid Dentin (Grupo FLD), Adhesivo universal+Resina universal (Grupo Control), Imprimación de aleación+Constic (Grupo APC), Imprimación de aleación+Fusio Liquid Dentin (Grupo APFLD), Imprimación de aleación+Adhesivo universal+Resina universal (Grupo APControl)]. Después de la prueba de resistencia al cizallamiento, los modos de fractura se determinaron bajo un microscopio digital. El análisis estadístico se realizó mediante análisis de varianza unidireccional y la prueba post hoc de Tukey. Resultados: Se obtuvieron los valores de resistencia al cizallamiento más altos para Fusio Liquid Dentin, entre los tres materiales de reparación cuando no se aplicó Alloy Primer (p<0.05). El uso de Alloy Primer aumentó los valores de resistencia al cizallamiento de los materiales de reparación investigados para la amalgama, excepto Fusio Liquid Dentin. Conclusión: Dentro de las limitaciones de la presente investigación, se puede concluir que; los materiales compuestos autoadhesivos investigados podrían ser alternativas que ahorran tiempo con respecto al adhesivo universal+resina universal con el fin de reparar las amalgamas, en términos de resistencia a la cizalladura. Los clínicos podrían preferir el material compuesto autoadhesivo Fusio Liquid Dentin sin la aplicación Alloy Primer con el fin de reparar amalgamas en pacientes poco cooperadores.

Solving color irregularities with a bioactive bulk-fill restorative system: case report and 24-months follow up / Resolución de irregularidades de color con un sistema restaurador bulk-fill bioactivo: reporte de caso y seguimiento de 24 meses

Bulk-fill resin composites represent an excellent alternative to the conventional incremental layering technique for the reduction of polymerization stress on the adhesive interface. Marginal seal can be further improved by the incorporation of bioactive fillers, such as those encountered in Giomers. However, the high translucency required for the adequate polymerization of bulk-fill materials can seriously jeopardize the final aesthetic outcome of the restorations, especially in the presence of inhomogeneous or stained dentin substrates. The aim of this case report was to present the combined use of two bulk-fill Giomer materials (Beautifil Bulk Flowable and Beautifil II LS, Shofu) for the restoration of three posterior maxillary teeth displaying a black stained dentin substrate due to amalgam corrosion products. This technique allowed completion of the restorations with a satisfactory aesthetic and biomimetic outcome. The adequate preservation of the anatomy and function of the three restorations after 24-months follow-up, provides evidence of the enhanced marginal sealing capacity of these bioactive materials and the success of bulk-fill techniques over time.

Las resinas compuestas de tipo bulk-fill representan una excelente alternativa a la técnica incremental para la reducción de la tensión de polimerización sobre la interfaz adhesiva. La incorporación de rellenos bioactivos, como los que se encuentran en los materiales con tecnología giomer, refuerzan aún más el sellado marginal de estas restauraciones. Sin embargo, la alta translucidez, necesaria para la adecuada polimerización de los materiales tipo bulk-fill, puede comprometer seriamente el resultado estético final de las restauraciones, especialmente en presencia de sustratos dentarios no homogéneos u oscurecidos. El objetivo de este reporte de caso fue presentar el uso combinado de dos materiales giomer tipo bulk-fill (Beautifil Bulk Flowable y Beautifil II LS, Shofu) para la restauración de tres dientes maxilares posteriores con un sustrato dentinario ennegrecido debido a productos de corrosión de amalgama. Esta técnica permitió completar las restauraciones con un resultado estético y biomimético satisfactorio. La adecuada conservación de la anatomía y la función de las tres restauraciones tras un período de 24 meses, aporta evidencia sobre la adecuada capacidad de sellado marginal de estos materiales bioactivos y el éxito de las técnicas de restauración tipo bulk-fill en el tiempo.

Pigmented Lesions.

Oral pigmented lesions have a wide range of clinical presentations, some of which correlate with cutaneous pigmented lesions. This article highlights these correlates and underscores important differences that can potentially have clinical impact. Moreover, given a nonspecific presentation of an oral pigmented lesion, the article provides a reference to aid clinicians with differential diagnoses based on clinical features. This article is an overview of pigmented lesions of the oral cavity, including localized reactive pigmented lesions, neoplastic pigmented lesions, and pigmented lesions as sequelae of a systemic disease.

Evaluation of mercury release from dental amalgam after cone beam computed tomography and magnetic resonance imaging with 3.0-T and 1.5-T magnetic field strengths.

OBJECTIVES: This in vitro study aimed to investigate leakage of mercury from amalgam restorations after cone beam computed tomography (CBCT) and magnetic resonance imaging (MRI) examinations. STUDY DESIGN: In total, 238 amalgam disks were prepared and placed in saline solution. The samples were allocated randomly to 7 groups, with 34 samples in each group. CBCT imaging was performed for 4 groups with different imaging parameters (narrow/wide field of view [FOV]; standard/high-resolution). MRI procedures were performed with 3.0-T and 1.5-T magnetic field strengths. No imaging was performed for the samples in the control group. The amalgam samples were removed from the tubes 24 hours after imaging and submitted for plasma mass spectrometry analysis. Kruskal-Wallis and Dunn's tests were performed to compare data. A P value less than .05 was accepted as statistically significant. RESULTS: The highest mean mercury value was found in the 3.0-T MRI group, whereas the lowest mean value was found in the narrow FOV, standard-resolution CBCT group. There were no significant differences between the control group and the experimental groups (P ≥ .338) or between the experimental groups (P > .05). CONCLUSIONS: CBCT and MRI procedures similar to those used in patient care caused no significantly different mercury release compared with nonexposed samples.

[Mercury exposure and dentists' health status in two regions of centrall Morocco: descriptive cross-sectional survey]. / Exposition au mercure et état de santé des médecins dentistes de deux régions du centre du Maroc: enquête transversale descriptive.

INTRODUCTION: mercury exposure is recognized as a worldwide public health concern. However, the effect of long-term exposure to low-doses of this heavy metal is still subject to debate. Due to the use of mercury in dental amalgam, dental health care professionals are chronically exposed to low-doses of this metal. In this context, we have conducted a descriptive cross-sectional survey among liberal dentists in two regions of the center of Morocco. In parallel, the global health status of participants was investigated to assess the relevance of a subsequent etiological survey. METHODS: data were collected through a self-reported questionnaire. Occupational exposure of dentists to mercury was evaluated based on their use of dental amalgam. Moreover, the other common factors increasing the background pollution or inducing exposure peaks were also investigated. On the other hand, smoking, vaccination, fish consumption, and the number of dental amalgam in mouth were considered as non-occupational exposure sources. Finally, the self-reported global health problems of participants were collected. RESULTS: 192 dentists were included in the present study. Seventy-six percent (76.04%) of them declared using dental amalgam in their practice. Moreover, the presence of dental amalgam in mouth was identified as the main non-occupational source of exposure to mercury (63.45% of participants). Finally, most of participants (46.35%) have expressed neuropsychological complaints. CONCLUSION: altogether, our results revealed a real mercury exposure in the studied population. Thus, effective preventive measures should be promoted to minimize the mercury exposure in dental offices. Moreover, an etiological study will be of great interest to reveal the impact of mercury exposure in this population.